Comprehensive analysis of correlation coefficients estimated from pooling heterogeneous microarray data

Integrating Heterogeneous Microarray Data Sources Using Correlation Signatures

Microarrays are one of the latest breakthroughs in experimental molecular biology. Thousands of different research groups generate tens of thousands of microarray gene expression profiles based on different tissues, species, and conditions. Combining such vast amount of microarray data sets is an important and yet challenging problem. In this paper, we introduce a “correlation signature” method...

a comprehensive comparison of different clustering methods for reliability analysis of microarray data

in this study, we considered some competitive learning methods which include hard competitive learning (hcl) and soft competitive learning (scl) with/ without fixed network dimensionality for reliability analysis in microarrays. in order to have a more extensive view, and keeping in mind that competitive learning methods aim at error minimization or entropy maximization (different kinds of func...

Integrating data from heterogeneous DNA microarray platforms

DNA microarrays are one of the most used technologies for gene expression measurement. However, there are several distinct microarray platforms, from different manufacturers, each with its own measurement protocol, resulting in data that can hardly be compared or directly integrated. Data integration from multiple sources aims to improve the assertiveness of statistical tests, reducing the data...

Data Models for Exploratory Analysis of Heterogeneous Microarray Data

A comprehensive analysis of the effect of microarray data

Background: Microarray data preprocessing, such as differentially expressed (DE) genes selection, is performed prior to higher level statistical analysis in order to account for technical variability. Preprocessing for the Affymetrix GeneChip includes background correction, normalisation and summarisation. Numerous preprocessing methods have been proposed with little consensus as to which is th...